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KMID : 0895820060160010093
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Journal of Oriental Rehabilitation Medicine
2006 Volume.16 No. 1 p.93 ~ p.107
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The Inhibitory Effect of Soeuminbang (SEIB) on the Obesity
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Shin Hong-Jung
Kang Jun-Hyuk
Yoon Il-Ji
Choi Seung-Hoon
Oh Min-Seok
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Abstract
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Objectives: This experimental study was designed to investigate the effects of Soeuminbang(SEIB) on obese mice.
Methods: In order to investigate the obese inhibitory effects of SEIB, C57BL/6 mice were induced by high fat diet. C57BL/6 mice were divided into three group(normal, high fat diet, high fat diet with SEIB extract) and fed for 13weeks. The measurements have been performed on ; the weight ; the quantity of AST, ALT, cholesterol, triglyceride, total protein, albumin ; and the quantity of obesity gene expression.
Results: Soeuminbang(SEIB) decreased with the significance the body weight change and the final increase of body weight in obese-mouse. SEIB decreased with the significance the weight of adipocyte in obese-mouse and also decreased the blood level of serum ALT, AST, total cholesterol, LDL-cholesterol and trigriceride, total protein and albumin in obese-mouse. SEIB increased β3AR gene expression in primary adipocytes isolated from obese-mouse and decreased leptin expression in adipocytes tissue isolated from obese-mouse. SEIB decreased GLUT1 and GLUT4, TNF-α expression in primary adipocytes isolated from obese-mouse.
Conclusions: Based on these results, it is proved that SEIB is effective on obesity care and has obese-inhibitory effects in obese-mouse induced by high fat diet. So it is respected that the clinical application of SEIB can help the treatment of obesity.
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KEYWORD
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Soeuminbang, Obesity, Body weight, Adypocyte
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